ECTS: 15
Hovedvejleder: René Holm, reho@sdu.dk, 65502375
Medvejleder
Nadina Zulbeari, SDU (FKF) nazu@sdu.dk, 65507597
Mathias Dam Mønster Sørensen (FKF) mathiasdms@sdu.dk, 65509333
Baggrund for projektet
Suspensions are often used as formulations intended for long-acting injectables (LAIs) as the size of the particles can be used to adjust the duration of the compound release after intramuscular or subcutaneous injection. Suspension, as disperse systems, are inherently thermodynamic unstable, hence the formulator should work with ensuring that the suspension is stable during shelf-life, e.g. by the addition of surfactants and polymers. Smaller particles are theoretical more instable than larger particles and they may tend to grow faster in size often driven by Ostwald ripening.Ostwald ripening is driven by surfactant solubilization, hence there may be arguments to assume that in a two component suspension smaller particles may stabilize a suspension with a compound with larger particles, however, this have never been evaluated.
The project will therefore work with different model compounds that is milled to two different sizes and mixed into one suspensions to learn what this do to the overall stability of both the small and large particle size populations.
Problemformulering
Does mixing of suspensions with different particle sizes lead to an overall stabilization or destabilization of the formulation?
Metoder
Suspensions will be prepared using media milling by dual centrifugation and characterized by laser diffraction and microscopy. Solubility in the stabilizer media will be investigated by HPLC
All data generated are physical-chemical in nature, hence not associated with any special ethical concerns. All raw data are collected and organized in an easy-to-understand way – and handed over to the supervisor at the end of the project.
Vejledning
Biweekly meetings that include data presentation and interpretations for discussions. Daily interactions are also available for guidance.