ECTS: 15
Hovedvejleder: René Holm, reho@sdu.dk, 65502375
Medvejleder
Nadina Zulbeari, SDU (FKF) nazu@sdu.dk, 65507597
Mathias Dam Mønster Sørensen (FKF) mathiasdms@sdu.dk, 65509333
Baggrund for projektet
Aqueous nano- and microsuspensions are used as a formulation platform for the preparation of long-acting injectables which can provide a prolonged release of an active compound after a single injection. The intended release can be altered by the adjustment of the particle size profile which is typically achieved by different size reduction approached such as wet bead media milling. During size reduction, the area at the solid-liquid is increased, driving the system towards a thermodynamic unstable state, which ultimately can result in particle agglomeration, i.e., increases in sizes of drug particles. Suitable stabilizers comprised of surfactants and/or polymers are therefore required to maintain the physical stability of the prepared suspensions – thus with the prerequisite that the stabilizer can sufficiently adsorb on the drug particle surface to provide proper wetting and stabilization both during milling and the subsequent storage by either electrostatic repulsion or steric stabilization. A few cases of a synergistic stabilization efficiency have previously been reported when surfactants or a surfactant and polymer were combined1,2,3 making it of interest to properly understand the stabilization efficiency of dual-surfactant systems in an attempt to improve the physical stability of nano- and microsuspensions.
This project with work with a large variety of different stabilizers in various combinations and concentrations/ratios to determine the stabilization efficiency of nano- and microsuspensions when combined in an attempt to improve the stability of selected drug suspensions. Milled suspensions will be studied with regard to the particle sizes as a function of time to evaluate the physical stability.
Problemformulering
Can the combination of different surfactants enhance the physical stability of nano- and microsuspensions?
Metoder
Nano- and microsuspensions are prepared with dual centrifugation and characterized with a laser diffraction and potentially XRPD during stability studies.
All data generated are physical chemical in nature, hence not associated with any special ethical concerns. All raw data are collected and organized in an easy-to-understand way – and handed over to the supervisor(s) at the end of the project.
Vejledning
Biweekly meetings that include data presentation and interpretations for discussions. Daily interactions are also available for guidance.
Referencer
1. Bilgili, E., Li, M., & Afolabi, A. (2016). Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions?. Pharmaceutical development and technology, 21(4), 499–510. https://doi.org/10.3109/10837450.2015.1022788
2. Li, M.; Lopez, N.; Bilgili, E. 2016. A study of the impact of polymer–surfactant in drug nanoparticle coated pharmatose composites on dissolution performance. Adv. Powder Technol., 27, 1625–1636. https://doi.org/10.1016/j.apt.2016.05.026
3. Zulbeari, N., Hansen, S. M., & Holm, R. (2024). Two in One: Size Characterization and Accelerated Short-Term Physical Stability of Dual-Drug Suspensions with Two Acidic Compounds (Indomethacin and Naproxen). Pharmaceutics, 16(12), 1495. https://doi.org/10.3390/pharmaceutics16121495